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Isolated optic neuropathy due to folate deficiency with associated iron overload
  1. Karina Pique1,
  2. William Taber2,
  3. Anthony Thompson2 and
  4. Charles Gerry Maitland2
  1. 1Clinical Sciences, Florida State University, Tallahassee, Florida, USA
  2. 2Clinical Sciences, Florida State University College of Medicine, Tallahassee, Florida, USA
  1. Correspondence to Dr Charles Gerry Maitland; gerry.maitland{at}


Isolated optic neuropathy due to folate deficiency is rarely reported. Poor dietary practices, malabsorption, and tobacco/alcohol abuse are usually responsible. We examined a patient with blinding optic neuropathies and isolated folic acid deficiency. Visual acuity recovered after folate replacement. At the same time, serological investigation revealed high ferritin and iron saturation levels with negative genetic markers for haemochromatosis consistent with the diagnosis of iron overload syndrome. There are no reports of blindness associated with iron overload syndrome.

  • nutrition
  • neurology (drugs and medicines)

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  • KP, WT and AT are joint first authors.

  • Contributors KP is the lead author on this study and WT is the second author. AT is a second author was involved in editing and manuscript prepartion. CGM oversaw the study. Additionally, KP and AT are not doctors. The author input system would not allow us to edit that information.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer-reviewed.