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Larynx lymphoepithelial carcinoma: surgical management
  1. Cosimo Galletti1,
  2. Cristina Pizzimenti2,
  3. Vittorio Cavallari2 and
  4. Bruno Galletti1
  1. 1Department of Adult and Development Age Human Pathology 'Gaetano Barresi', Unit of Otorhinolaryngology, Universita degli Studi di Messina, Messina, Italy
  2. 2University of Messina, Messina, Sicilia, Italy
  1. Correspondence to Dr Cosimo Galletti; cosimogalletti92{at}


Lymphoepithelial carcinoma (LEC) is an entity mostly frequent in the nasopharynx, which represents 40% of all neoplasms. The incidence’s not exclusive of a geographic area; however, it has an endemic distribution in Southeast Asia and Eskimos. LEC is not exclusive of the nasopharynx, has also been reported in other anatomical areas, such as the sinonasal tract, nasolacrimal duct, oral cavity, oropharynx, salivary glands, thymus, hypopharynx, oesophagus, stomach, trachea, lung and others. Non-nasopharyngeal and nasopharyngeal LEC have the same microscopic features, but the nasopharyngeal is more likely associated with Epstein-Barr virus. LEC has been approved by the WHO. LEC located in the larynx is quite rare and worthy of attention for its implication in the treatment and prognosis. We present a case of LEC treated in our ENT department in a middle-aged man.

  • ear
  • nose and throat/otolaryngology
  • otolaryngology / ENT
  • head and neck cancer

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  • Contributors CG and BG developed the concept and design of the study and treated the patient. CG is the corresponding author. CG and BG performed follow-up examinations and literature research.VC and CP performed histological examination. BG and VC critically revised the manuscript for important intellectual content and gave the final approval of the version to be submitted.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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