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Leiomyomatosis peritonealis disseminata with endometriosis
  1. Bo Ram Yu1,
  2. Sun Young Lee2 and
  3. Dong Hyu Cho3
  1. 1Department of Obstetrics and Gynecology, Jeonbuk National University Hospital, Jeonju, The Republic of Korea
  2. 2Department of Radiation Oncology, Jeonbuk National University Medical School, Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute, Jeonbuk National Uinversity Hospital, Jeonju, Jeollabuk-do, The Republic of Korea
  3. 3Department of Obstetrics and Gynecology, Jeonbuk National University Medical School, Research Institute of Clincal Medicine of Jeonbuk National University-Biomedical Research Institute, Jeonbuk National University Hospital, Jeonju, The Republic of Korea
  1. Correspondence to Professor Dong Hyu Cho; obgyn2001{at}

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A 49-year-old female patient was transferred to our hospital due to suspicion of severe adhesion and malignant tumours during surgery at a local hospital with an adnexal tumour a week ago. There was no history of gynaecological surgery before this surgery.

On pelvic examination, a solid, fixed mass as large as small fist was palpated in the left adnexal region of the uterus. Her body mass index was 25.6 kg/m2. As routine, her full blood counts and serum biochemistry were within the normal ranges. The serum cancer antigen 125 level was elevated (44.0 U/mL).

Transvaginal ultrasonography revealed a solid mass measuring 4.3×5 within the left adnexa. Contrast-enhanced CT images of the abdomen and pelvis showed a 6.5×5 cm sized mass with heterogeneous enhancement within the left adnexa and multiple nodular lesions in the pelvic cavity (figure 1).

Figure 1

Contrast-enhanced CT of the abdomen and pelvis shows a mass with heterogeneous enhancement at the left ovary and multiple areas of pelvic nodularity suspicious of pelvic seeding (arrows).

It was presumed to be a malignant ovarian tumour and exploratory laparotomy was performed. The left adnexal mass observed on ultrasound was determined to be a hard, round ovarian mass that was adhered to the left fallopian tube and the mesentery of the sigmoid colon. Right adnexa had a grossly normal appearance. Innumerable small nodules were present in the mesentery, the omentum, uterus and the serosal surface of the sigmoid colon (figure 2). Intraoperative frozen section analysis suggested a benign mesenchymal tumour. She underwent total hysterectomy, left unilateral salpingo-oophorectomy and sigmoid colectomy with optimal resection of the disseminated nodules.

Figure 2

Intraoperative findings reveal multiple nodules with smooth surface, which are adhesive with fallopian tube, mesentery of the colon and omentum.

Histopathological examination of the resected nodules revealed them to be less than 1×3 mm in the peritoneum and 19×17×12 mm in the omentum. These nodules were composed of smooth muscle cells arranged in fascicles. In addition, this nodule included haemorrhaging endometrial tissue with smooth muscle cells. The nodule was positive for oestrogen receptors and progesterone receptors (figure 3). According to these results, the final diagnosis was leiomyomatosis peritonealis disseminata (LPD) with endometriosis.

Figure 3

Histologic features (A) there are multiple tiny-sized white grey nodules on the surface of the uterus, fallopian tube and sigmoid colon. (B) Endometrial gland and stromal cells without atypia, H&E stain, ×200.

The patient was discharged 1 week after surgery and was treated with ulipristal acetate for 3 months. During the follow-up for 5 years, she is doing well without recurrence.

LPD is a rare, benign disease in premenopausal and postmenopausal women. Although the mechanism of LPD has still not been established, high estrogenic status is considered as a causative factor. Reproductive age, prolonged use of oral contraceptives, hormonal replacement therapy and estrogen-secreting tumour may induce LPD according to several case reports.1 2 Similarly, endometriosis is one of the well-known estrogen-dependent diseases, and several cases of LPD with endometriosis have been reported.3 One possibility is that it might be connected to a ‘Müllerianosis condition.’ Leiomyomatous nodules might be derived from the Müllerian epithelium. Smooth muscle might be contained sufficiently below the peritoneum in the pelvic cavity.4 A high serum oestrogen level may stimulate the proliferation of Müllerian derivatives to LPD. In our case, the ovarian malignant tumour was the presumptive diagnosis and the oestrogen level was not evaluated before the operation. However, it is most likely caused by an increase in oestrogen.

With the absence of a consensus regarding the treatment of LPD, we can only speculate on possible treatment options for LPD. A surgical approach should be considered to confirm the diagnosis. Lowering the serum estrogen level might be the primary postoperative treatment in addition to radical resection. Aromatase inhibitors or gonadotropin-releasing hormone agonists have also been proposed by several reports.5

Learning points

  • ‘Müllerianosis’ may explain leiomyomatosis peritonealis disseminata mixed with endometriosis in the peritoneal cavity.

  • Lowering the serum estrogen level might be the primary postoperative treatment in addition to radical resection.

Ethics statements



  • Contributors BRY, SYL, DHC: Designed and performed experiments, the acquisition of data and co-wrote the paper. SYL: Designed the conception of the study and co-wrote the paper. DHC: Designed and performed experiments, supervised the research and co-wrote the paper.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.