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Generalised eruptive histiocytosis preceded by systemic symptoms
  1. Caitlyn N Myrdal1,
  2. Delaney B Stratton1,
  3. Tracy L Davis2 and
  4. Clara Curiel-Lewandrowski1
  1. 1Dermatology Division, The University of Arizona College of Medicine Tucson, Tucson, Arizona, USA
  2. 2Dermpath Diagnostics, Quest Diagnostics, Tucson, Arizona, USA
  1. Correspondence to Caitlyn N Myrdal; cmyrdal{at}


Generalised eruptive histiocytosis is a rare proliferative disease that typically presents with indolent cutaneous eruptions. We describe the case of a 73-year-old man presenting with diffuse, asymptomatic crops of pink to dusky red papules preceded by general malaise, myalgias, fluctuating fever, chills, and weight loss. Histological evaluation revealed a non-Langerhans cell histiocytic dermal infiltrate with spindle cell features and chronic inflammation, reactive for CD68 and negative for both S100 and CD1a. Malignancy screening was negative. This report aims to highlight a unique presentation of generalised eruptive histiocytosis, emphasise histological findings, and discuss considerations for malignancy screening.

  • Dermatology
  • Screening (oncology)
  • Pathology

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  • Contributors Conception and design of manuscript: CNM and CC-L. Main drafting of manuscript: CNM. Revision and editing of manuscript: TLD, CC-L and DBS. Clinical care of patient: CC-L and DBS. Histological analysis and histological image acquisition: TLD.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.