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Proliferative glomerulonephritis with monoclonal immunoglobulin deposits associated with parvovirus B19
  1. Rosalba Santana de Roberts1,
  2. Ibrahim Batal2,
  3. Amr Aljareh1 and
  4. Belinda Jim1
  1. 1Department of Medicine, Jacobi Medical Center, Bronx, New York, USA
  2. 2Department of Pathology, NewYork-Presbyterian Hospital, New York, New York, USA
  1. Correspondence to Dr Belinda Jim; belindajim286{at}gmail.com

Abstract

Proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID) is included in the group of dysproteinaemias causing renal disease. Only a minority of cases are associated with a haematological malignancy. Two cases have been linked to acute parvovirus B19 infections. We report a 36-year-old African-American woman who presented with renal dysfunction, proteinuria, haematuria and a kidney biopsy reported as PGNMID with IgG3-kappa deposits. Her evaluation for a haematological malignancy was unrevealing. Her parvovirus IgM and IgG levels were positive. The patient was initially treated with an ACE inhibitor and spontaneously remitted with minimal proteinuria after 1 month. Repeat parvovirus B19 serologies 6 months later showed persistent IgG and DNA by PCR positivity but IgM negativity. Given the clinical scenario, we believe that her PGNMID was induced by acute parvovirus B19 infection, which appeared to resolve once her acute infection abated. In this report, we describe our latest understanding of PGNMID.

  • nephrotic syndrome
  • proteinurea
  • immunology
  • drugs: infectious diseases

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Footnotes

  • Contributors RSdR contributed to researching, editing and writing of the paper. IB contributed to the pathological interpretation of the renal biopsy and editing of the paper. AA contributed to editing of the paper. BJ contributing to research, editing and writing of the paper.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.