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Virilising adrenocortical carcinoma
  1. Diogo Nunes Correia,
  2. Inês Redondo de Carvalho and
  3. Jeenal Assuani Mangi
  1. Universidade Nova de Lisboa Faculdade de Ciências Médicas, Lisboa, Portugal
  1. Correspondence to Jeenal Assuani Mangi; a2015250{at}


Adrenocortical carcinoma (ACC) is a rare malignancy, with an estimated annual incidence of 0.7–2 cases per million and a median overall survival of 3–4 years. Hormone-secreting ACCs represent most cases; of these, only a small minority presents with virilisation alone. Early diagnosis is key to increase the chances of a better outcome. Here, we report a case of a 41-year-old woman who presented with menstrual irregularities, hirsutism and virilising symptoms, associated with abdominal discomfort and constitutional symptoms. On physical examination, there was a palpable mass in the right upper quadrant. Laboratory workup revealed elevated serum androgens. The imaging study showed a 163×110×122 cm right adrenal mass with features consistent with ACC and suggested potential hepatic invasion. Our patient underwent surgical resection, and the histopathological findings confirmed the diagnosis. She was referred to a specialised centre for follow-up and adjuvant therapy.

  • endocrine cancer
  • general surgery
  • adrenal disorders
  • surgical oncology

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  • Contributors DC, IRdC and JM conceived and designed the manuscript, acquired and interpreted the data, drafted the article and critically revised it. DC, IRdC and JM approved the final version of the manuscript to be published.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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