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Bullous pemphigoid-like rash revealing hypereosinophilic syndrome
  1. Mehdi Khallaayoune,
  2. Sanae Sialiti,
  3. Mariame Meziane and
  4. Karima Senouci
  1. Department of Dermatology, Mohammed V University of Rabat, Rabat, Morocco
  1. Correspondence to Dr Mehdi Khallaayoune; khallaayounemehdi{at}


Hypereosinophilic syndrome (HES) is a rare haematologic disorder characterised by unexplained, persistent eosinophilia with organ involvement. We report the case of a 74-year-old patient who presented with a pemphigoid-like bullous rash as the only manifestation of an HES. This report highlights the importance of the dermatological manifestations of this potentially life-threating condition that may initially present as a skin-limited disease. Bullous pemphigoid (BP) is a very common autoimmune blistering dermatosis that may share common clinical and histological features or associate with an HES. HES should be considered when patients diagnosed with BP demonstrate atypical course under corticosteroids and/or recalcitrant blood eosinophilia.

  • dermatology
  • haematology (incl blood transfusion)
  • pathology

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  • Contributors MK: contributed in conception, design and drafting of the article, participated in patient’s care. SS: contributed in literature review, design and drafting of the article. MM and KS: made corrections and revisions.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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