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Case of eustachian valve endocarditis and the importance of synergistic antibiotic therapy
  1. Dilpat Kumar1,
  2. James Boyer2,
  3. Warsha Fnu3 and
  4. Harry Boamah4
  1. 1Western Michigan University Homer Stryker MD School of Medicine, Kalamazoo, Michigan, USA
  2. 2Internal Medicine Department, Western Michigan University Homer Stryker MD School of Medicine, Kalamazoo, Michigan, USA
  3. 3Internal Medicine, Interfaith Medical Center, Brooklyn, New York, USA
  4. 4Medicine, Division of Infectious Diseases, Western Michigan University Homer Stryker MD School of Medicine, Kalamazoo, Michigan, USA
  1. Correspondence to Dr Dilpat Kumar; dilpat.kumar{at}med.wmich.edu

Abstract

A 46-year-old woman with a history of end-stage renal disease on chronic haemodialysis presented with 1 week of fever, chills, altered mental status and hand pain. She was febrile and ill-appearing on presentation with a pulse rate of 102 beats per minute. She had a tunnelled dialysis catheter in her right neck. Hand examination demonstrated a swollen, erythematous and tender wrist. Cardiovascular examination demonstrated no murmurs. CT of the hand showed abscesses involving the left forearm. Blood and abscess cultures grew methicillin-resistant Staphylococcus aureus (MRSA). Transesophageal echocardiography (TEE) showed a 1.0×1.0 cm mobile vegetation involving the eustachian valve (EV), confirming EV endocarditis. She remained bacteraemic for 18 days despite being on vancomycin with appropriate blood levels. Vancomycin was switched to daptomycin and ceftaroline, which cleared her cultures. Repeat TEE showed improved vegetation size. Our case highlights the rarity and management of EV endocarditis and the importance of synergy for treatment of persistent MRSA bacteraemia.

  • cardiovascular medicine
  • infections
  • infectious diseases
  • drug interactions
  • cardiothoracic surgery

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Footnotes

  • Contributors DK edited and reviewed the manuscript. JB wrote the first draft and reviewed the literature. FNUW helped to revise the first draft. HB reviewed the final draft.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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