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Denosumab and bisphosphonate associated bilateral osteonecrosis of the external auditory canal
  1. Harry David True1,
  2. Rupert George Ricks2 and
  3. Joel Anthony Smith2
  1. 1University of Exeter Medical School, Exeter, UK
  2. 2Ear, Nose and Throat (ENT) Department, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK
  1. Correspondence to Joel Anthony Smith; joel.smith2{at}


We present a case of non-surgically managed bilateral osteonecrosis of the external auditory canal with a history of long-term medical therapy for osteoporosis. A 79-year-old woman with severe osteoporosis and destructive osteoarthritis received >10 years of once weekly bisphosphonate therapy before switching to denosumab. Four months later, the patient presented with bilateral loss of hearing and right-sided otalgia. Necrotising otitis externa, cholesteatoma and malignancy were considered but with histology, microbiological and CT assessment, bilateral osteonecrosis of the external auditory canal was diagnosed. Surgical debridement with canalplasty was avoided due to our patient’s comorbidities. Treatment continued for 5 months with regular aural toilet, Terra-Cortril ointment and bismuth-iodine-paraffin paste packing. At 1-year follow-up, bilateral external auditory canals were completely re-epithelialised with no pain or affected hearing. We report the first case of bilateral osteonecrosis of the external auditory canal associated with denosumab and bisphosphonates with successful conservative management.

  • ear
  • nose and throat/otolaryngology
  • calcium and bone
  • otitis
  • unwanted effects / adverse reactions
  • otolaryngology / ENT

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  • Contributors HDT was the main author. RGR was the treating clinician and coauthor. JAS was a coauthor.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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