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Catatonic syndrome as the presentation of encephalitis in association with COVID-19
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  1. Damaris Vazquez-Guevara1,
  2. Sandra Badial-Ochoa1,
  3. Karen M Caceres-Rajo2 and
  4. Ildefonso Rodriguez-Leyva1,3
  1. 1Neurology, Hospital Central Dr Ignacio Morones Prieto, San Luis Potosi, Mexico
  2. 2Internal Medicine, Facultad de Medicina, Universidad Autonoma de San Luis Potosi, San Luis Potosi, Mexico
  3. 3Facultad de Medicina, Universidad Autonoma de San Luis Potosi, San Luis Potosi, Mexico
  1. Correspondence to Dr Ildefonso Rodriguez-Leyva; ilrole{at}yahoo.com.mx

Abstract

COVID-19 has shown different neurological manifestations even sometimes there are the initial or the main presentation.

The following case report is about a middle-aged woman who, over 3 days, developed fever, clinical neurological alterations (stupor, muteness, fixed gaze and catatonia), cerebrospinal fluid (16 lymphocytes) and an electroencephalogram (EEG) (4–6 Hz generalised activity) with characteristics of encephalitis. A serum IgG, IgM, nasopharyngeal swab PCR for SARS-CoV-2. The patient responded positively to support measures, symptomatic and corticosteroid treatment. At discharge, the patient was independent and improved considerably.

We report the presence of catatonia as a possible and atypical manifestation of encephalitis in association with COVID-19.

  • COVID-19
  • infectious diseases
  • neurology
  • infection (neurology)

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Background

Much of the focus regarding the COVID-19 pandemic was initially centred on cardiovascular, pulmonary and haematologic complications. However, the prevalence of neurological symptoms in these patients has become more evident.1 One of these conditions is catatonia, described in 1874 by Karl Kahlbaum as a very diverse psychomotor syndrome with a clinical picture ranging from mutism, catalepsy agitation to echolalia, echopraxia and stereotypes.2 The most common aetiology of catatonia is a psychiatric illness, and there were reports of other general medical conditions. The frequency of catatonia due to general medical conditions represents 20%–39% of aetiology in catatonia syndrome.3 The most common neurological aetiologies were metabolic encephalopathy, autoimmune, paraneoplastic and infectious encephalitis.4

The mechanism used by a virus to cause neurological damage is an immune dysregulation associated with a failure in motor connectivity; this suggests dysfunction of the movement circuit (thalamus, cerebellum, pontine nuclei, the corticocortical pathways, the supplementary motor area, among others), with a cytokine-related injury, damage to specific receptors, inflammation and secondary hypoxia along nerve fibres.5

Case presentation

A 43-year-old woman was brought to the emergency department suffering from stupor, silence and staring. Three days prior, her husband noticed that the patient had apathy, slow thinking and decreased mobility. On presentation to the emergency department, her heart rate was 110 beats per minute. Neurological examination revealed stupor, muteness, fixed gaze, negativism, stiffness in the left hemibody, gegenhalten sign on the right side of the body, global hyperreflexia and no neck stiffness. The Bush-Francis Catatonia rating scale was 19 points. The approach was based on catatonic syndrome (video 1). Initially, a CT scan of the head was requested without alterations. An electroencephalogram (EEG) showed generalised slow activity (figure 1). Even during the EEG, the patient had motor stereotypes that did not correlate with brain activity. Initial blood test reported a white cell count of 9.5×109 (reference range 4–11), C reactive protein of 5.7 mg/L. Serum electrolytes, creatine phosphokinase, the liver and renal functions were normal, and thiamine levels were unremarkable. Lumbar puncture revealed an opening pressure of 17cm H2O. The white blood cell count in the cerebrospinal fluid (CSF) was 16 mm3 (100% lymphocytes). Treatment with acyclovir for the probable viral encephalitis and a diazepam infusion for the catatonic syndrome was started.

Uncited Video 1
Figure 1

Electroencephalogram was showing slow generalised theta activity of 4–6 Hz.

On day 2 of admission, she had a cough, a fever of 102.92°F (39.4°C), and 88% oxygen saturation on pulse oximetry. On examination, chest auscultation was normal. CT of the chest showed basal bilateral pulmonary infiltrate. A serum IgG, IgM and a nasopharyngeal swab PCR test for the SARS-CoV-2 was performed.

CSF cytology was normal. The direct Gram stain of the CSF and CSF culture was negative, and PCR was negative for herpes virus (HSV) type 1 and 2. MRI of the brain showed no abnormalities.

The approach was then focused on autoimmune aetiology, and she was treated empirically with a bolus of methylprednisolone 1 g per day for 5 days.

On day 3 of admission, she presented with orofacial dyskinesias, upper limb stereotypies and waxy postures. A thyroid nodule was detected with standard thyroid tests, antiperoxidase antibodies, and antithyroglobulin antibodies were negative. The histological report of the thyroid nodule was lymphoid hyperplasia.

Serum IgG and IgM and PCR were positive for SARS-CoV-2; the patient presented mild typical respiratory symptoms. The catatonic syndrome was related to encephalitis in association with COVID-19.

Differential diagnosis

Initially, our differential diagnosis included psychiatric catatonic syndrome (schizophrenia or bipolar syndrome) or organic brain disorders causes.6 The approach of the catatonic syndrome was for organic brain disorders.

On the day of admission, a CT of the head was performed to search for lesions such as brain haemorrhages and bi-frontal masses; however, it was unremarkable. Status epilepticus was suspected, so a trial with benzodiazepines was initially performed without clinical improvement. An EEG was conducted during which stereotypes were presented, which did not correlate with the brain activity generalised dysfunction.7

The differential diagnosis was then focused on the cause of encephalitis.8 An autoimmune aetiology was suspected. The pertinent screening was carried out where one thyroid nodule was identified, and a biopsy was performed, which led to a high suspicion of Hashimoto’s encephalitis.9 However, there was normal thyroid function, a pathology report of the thyroid nodule showed lymphoid hyperplasia, and negative antiperoxidase and antithyroglobulin antibodies were found.

The patient presented mild respiratory symptoms, and CT showed basal bilateral pulmonary infiltrate. Serum IgG, IgM and PCR were positive for SARS-CoV-2. CSF was not tested for SARS-CoV-2 because many reports did it and concluded the lack of PCR to detect SARS-CoV-2 on CSF.10 We could not rule out other possibilities due to the family’s economic limitations and our institution, such as other autoimmune limbic encephalitides (Anti-NMDA (N-methyl-D-aspartate) receptor, anti-LGI1 (Leucine-rich glioma-inactivated 1) and Anti-CASPR2 (Contactin Associated Protein 2).11 The encephalitis was classified as possibly viral and associated with a pulmonary process caused by COVID-19 and a rare manifestation of a catatonic syndrome.

Treatment

The initial treatment was for the catatonic syndrome with low doses of infusion diazepam with no good response. Initially, with probable viral encephalitis, the patient was under treatment with acyclovir only 2 days; it was discontinued after negative CSF PCR for HSV. The respiratory symptoms were treated with supplemental oxygen therapy.

Apart from acyclovir, no specific treatment was given for encephalitis due to a lack of diagnostic certainty. The patient was treated with an intravenous bolus of methylprednisolone for 5 days, and then she received oral prednisone.

Outcome and follow-up

There was a remarkable improvement when finished with the boluses of steroids. The patient awoke with significant cognitive decline characterised by the disorientation of time and a deficit of the working, short and semantic memory with 17 on the Montreal Cognitive Assessment in Spanish (MoCA-S) test. She also presented rest tremor on the right hand and hypokinesia, with hypokinesia on the left hemibody and rest tremor on the right hand.

At discharge from the hospital, the patient could walk and perform daily living activities such as bathing, eating and dressing.

Discussion

The COVID-19 pandemic infection is caused by the SARS-CoV-2. The primary manifestation is a respiratory syndrome, where the symptoms are fever, dry cough, fatigue, dyspnoea, chest pain, fatigue and myalgia.10 There are many neurological manifestations in the central nervous system and peripheral nervous system; these manifestations are considered direct effects of the nervous system’s virus, para-infectious or post-infectious immune-mediated disease.12 The neurological manifestations in the current COVID-19 pandemic are olfactory and taste disorders, dizziness, altered mental status, seizure, acute cerebrovascular disease, neuralgia, ataxia, Guillain-Barre syndrome and encephalitis.13 There are few case reports about encephalitis, where the main neurological clinical presentation was generalised seizures, altered mental state as confusion and meningism.8 The definitive diagnosis of encephalitis by SARS-COV-2 is difficult because the virus dissemination is transient, and its CSF titre may be extremely low.14 There is no specific treatment. Catatonia is reported as a clinical manifestation in infectious encephalitis, and its prevalence is unknown. The appropriate diagnostic workup of catatonia should be done. A recent case report described a man without a history of any neuropsychiatric condition, which initially developed respiratory symptoms due to COVID-19 then presented catatonia, also considered associated with drugs (azithromycin, methocarbamol).15 There are two other case reports of catatonia associated with COVID-19, one in a 61-year-old man with a history of schizophrenia16 and the other in an older man with diabetes, hypertension, atrial fibrillation who also developed catatonia associated with SARS-CoV-19 infection.17

Among the possibilities of neuropsychiatric presentations of coronavirus-associated infections, a systematic review and meta-analysis included catatonia as a possibility,18 associating the coronavirus pandemic in its acute phase of the disease to depression and anxiety in the majority of cases and in a minority of patients to psychosis and catatonia.19

This case report shows a patient with catatonic syndrome as the presentation of encephalitis in association with COVID-19. The catatonic syndrome could be considered an initial manifestation of encephalitis.

Patient's perspective

The patient and her family were delighted about the evolution and outcome of the problem.

Learning points

  • Neurological manifestation could be the initial manifestation of COVID-19.

  • It is always important to rule out typical infectious, autoimmune and paraneoplastic causes of encephalitis.

  • Catatonia syndrome can be a manifestation of encephalitis in association with SARS-CoV2 infection.

  • Encephalitis can give generalised dysfunction in the electroencephalogram without significant abnormalities on MRI of the brain.

  • If faced with a patient with catatonia in association with COVID-19 infection, the appropriate complementary tests should be carried out to make the differential diagnosis and subsequently establish an association.

Acknowledgments

IR-L is the corresponding author. He has the right to grant and grants on behalf of all authors. He gives an exclusive license to BMJ Publishing Group Ltd (‘BMJ’) and its licensors to allow this work, if accepted, to be published in BMJ Case Reports and any other BMJ product and to exploit all rights, as set out in our license.

References

Footnotes

  • Contributors DV-G and SB-O participated in the planning, writing and editing of the report. IR-L was the corresponding author. IR-L edited the report, figures and videos. KMC-R participated in the writing of the report.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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