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Splinter haemorrhages and brain infarcts as an unusual presentation of sarcoidosis
  1. Shazeen Ayub,
  2. Rand Hawari and
  3. Hamzah Mahmood-Rao
  1. Rheumatology Department, Royal Derby Hospital, Derby, UK
  1. Correspondence to Dr Shazeen Ayub; shazeen.ayub{at}


We present an interesting case of a healthy 47-year-old woman who presented to the acute take with symptoms of visual apraxia, splinter haemorrhages and extreme fatigue. This was a diagnostic challenge with other unusual features to this case, which includes brain infarcts on MRI, raised troponin and oeosinophilia. Naturally endocarditis was the top differential but this was ruled out by serial negative blood cultures and a negative transthoracic echocardiogram. Several medical specialties were involved and the initial working diagnosis was ANCA vasculitis (oeosinophilic granulomatosis with polyangiitis). Early administration of intravenous steroids clouded our judgement further and sarcoidosis was not thought as a possible differential. We illustrate the immensely challenging and complicated clinical course involving multiple specialties and investigations. In the end, a complete steroid wean was required to reach an accurate histological diagnosis.

  • vasculitis
  • connective tissue disease
  • respiratory medicine
  • infectious diseases
  • immunology

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  • Contributors SA and HM-R are coauthors to the paper. RH provided histology images for the report.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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