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Autoimmune gastritis concomitant with gastric adenoma and subacute combined degeneration of the spinal cord
  1. Masahiro Taniguchi1,
  2. Gota Sudo1,
  3. Yuzufumi Sekiguchi2 and
  4. Hiroshi Nakase1
  1. 1Department of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Sapporo, Japan
  2. 2Sapporo Medical University School of Medicine, Sapporo, Japan
  1. Correspondence to Dr Hiroshi Nakase; hiropynakase{at}


A 62-year-old woman was referred to our department for further investigation of anaemia. Blood test showed macrocytic anaemia. Oesophagogastroduodenoscopy (OGD) revealed proximal-predominant gastric atrophy and flat elevated lesion in the gastric body. Several days after OGD, she complained of gait disturbance and was diagnosed with subacute combined degeneration of the spinal cord. Furthermore, laboratory tests showed positive for both anti-parietal cell and anti-intrinsic factor antibodies, as well as increased serum gastrin level and decreased pepsinogen I level, which confirmed the diagnosis of autoimmune gastritis (AIG). Anaemia and neurological symptoms were improved after vitamin B12 supplementation. Subsequently, the patient underwent gastric endoscopic submucosal dissection; histopathological examination revealed gastric adenoma. AIG can cause gastric neoplasms and vitamin B12 deficiency, with the latter resulting in pernicious anaemia and neurological disorders. These diseases are treatable but potentially life-threatening. This case highlights the importance of early diagnosis of AIG and proper management of its comorbidities.

  • stomach and duodenum
  • endoscopy
  • spinal cord
  • vitamins and supplements

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  • Contributors MT, GS and YS conceived the study. MT and GS acquired clinical data. MT, GS, YS and HN interpreted clinical data. MT, GS and HN wrote the manuscript. HN performed critical revision of the article for important intellectual content.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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