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Xerophthalmia due to vitamin A deficiency following Frey’s procedure for chronic calcific pancreatitis
  1. Supriya Sharma1,
  2. Somasheila I Murthy2,
  3. Manjushree Bhate3 and
  4. Varsha Rathi1
  1. 1GPR-ICARE, LV Prasad Eye Institute, Hyderabad, Telangana, India
  2. 2Cornea Service, The Cornea Institute, LV Prasad Eye Institute, Hyderabad, Telangana, India
  3. 3Jasti V Ramanamma Children's Eye Care Center, LV Prasad Eye Institute, Hyderabad, Telangana, India
  1. Correspondence to Dr Somasheila I Murthy; smurthy{at}


We report a rare presentation of xerophthalmia due to partial pancreatic exocrine insufficiency following Frey’s surgery (pancreatic resection) in a 12-year-old girl. The child had undergone this surgery for chronic calcific pancreatitis 3 years before and presented with ocular irritation and decreased vision of 3 months duration. Ocular examination showed severe conjunctival and corneal xerosis. Her serum retinol levels and 25-hydroxyvitamin D were tested and were extremely low. The condition rapidly reversed following high-dose replacement therapy with vitamin A and D. This case highlights the importance of continuous enzyme replacement therapy as well as dietary modification and nutritional supplement therapy and monitoring of ocular symptoms in post-pancreatic surgery.

  • eye
  • nutrition
  • pancreatitis
  • ophthalmology

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  • Contributors SS and SIM contributed to concept, data acquisition and interpretation; SS, SIM, MB and VR drafted the article; SIM, VR and MB contributed to revision and final manuscript.

  • Funding This study was funded by Hyderabad Eye Research Foundation (LEC BHR-R-03-21-597).

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.