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Primary intramedullary spinal-cord lymphoma (PISCL): a rare entity with a challenging diagnosis
  1. Emanuel Santos Martins,
  2. Cristina Duque,
  3. Olinda Rebelo and
  4. Sónia Batista
  1. Neurology, Centro Hospitalar e Universitário de Coimbra EPE, Coimbra, Coimbra, Portugal
  1. Correspondence to Dr Emanuel Santos Martins; dsamartins.emanuel{at}


Primary intramedullary spinal-cord lymphoma (PISCL) is a rare cause of myelopathy and constitutes only 1% of central nervous system lymphomas. Delay to diagnosis is common due to its rarity, its similarity to other causes of myelopathy and the difficulties in obtaining pathological diagnosis. We report a case of PISCL and discuss the challenges faced on diagnosis, namely the impact of corticosteroids on histological findings, the usefulness of MRI, positron-emission tomography/CT (PET/CT) and repeated lumbar punctures.

  • neuroimaging
  • neurooncology
  • spinal cord
  • pathology
  • haematology (incl blood transfusion)

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  • Contributors ESM: acquisition, analysis and interpretation of data; wrote the original manuscript. CD: acquisition, analysis and interpretation of data. OR: acquisition, analysis and interpretation of data. SB: study concept and design; critical revision of the manuscript for important intellectual content.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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