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Idiopathic linear IgA bullous dermatosis treated with prednisone
  1. Christopher Cantoria Garces1,
  2. M Fahad Salam1,
  3. Brian Nohomovich2,3 and
  4. Merryl Treasa Varghese1
  1. 1Department of Medicine, Michigan State University College of Human Medicine, Lansing, Michigan, USA
  2. 2Michigan State University College of Osteopathic Medicine, East Lansing, Michigan, USA
  3. 3Department of Microbiology and Molecular Genetics, Michigan State University College of Natural Science, East Lansing, Michigan, USA
  1. Correspondence to Dr Christopher Cantoria Garces; garcesch{at}msu.edu

Abstract

We present a case of a 43-year-old man with a medical history of paroxysmal atrial fibrillation that presented with acute onset generalised vesiculobullous rash of 1-week duration. The rash was initially noticed on his groin and then spread to his hands, feet and mucosal surfaces. Laboratory tests were unremarkable, including an extensive infection aetiology work-up. Punch biopsies were obtained of a fresh lesion and were stained with H&E and sent for direct immunofluorescence. Light microscopy and immunofluorescence study demonstrated a subepidermal blister with predominant neutrophilic infiltrates and a linear band of IgA at the dermoepidermal junction, respectively. The patient was diagnosed with linear IgA bullous dermatosis and was subsequently treated with 0.5 mg/kg of prednisone daily following previous case reports. At 1-week follow-up as an outpatient, the bullae became crusted, and the rash was nearly completely regressed.

  • dermatology
  • drug interactions
  • immunology

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Footnotes

  • Contributors CCG, MFS and MTV worked on the case presentation and discussion. BN worked on the abstract and conclusion. CCG and BN proofread the draft. CCG, MFS, BN and MTV revised the final draft.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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