We describe an uncommon cause of paraneoplastic optic neuropathy in adenocarcinoma of the lung. A 45-year-old healthy woman presented with seizure and encephalitis, followed by an acute visual loss in both eyes for 1 week. Her visual acuity was no perception of light in the right eye and hand movement in the left eye. There was a generalised restriction of extraocular muscle movements in both eyes. Funduscopy showed a bilateral pale optic disc. A paraneoplastic antigen autoimmune profile showed a positive anti-CV2/CRMP-5 antibody. CT of the thorax revealed the presence of right apical lung mass, confirmed to be adenocarcinoma through a biopsy. She was scheduled for lung lobectomy and chemotherapy. Unfortunately, her health deteriorated and she passed away eventually.
- cancer intervention
- lung cancer (oncology)
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Contributors JYY was one of the physicians in charge of the patient we reported; responsible for writing up the case presentation and data collection, including the consent taking and obtaining the images;and involved in the literature review of the case report as well. W-HWH was the main physician in charge of the patient; provided important intellectual content for the discussion of the write up of the case presentation; and finalised the case report before submission. SAH was the neurologist in charge of the patient; provided expert opinion to co-manage the patient; and provided important intellectual content for the discussion of the case report. NAM was the physician in charge of the patient; assisted in data collection and provided intellectual content for the discussion of the case report.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Provenance and peer review Not commissioned; externally peer reviewed.
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