A man in his 50s with neutropenic fever and multifocal lung opacities was diagnosed with a viral pneumonia. A small number of bacteria grown from bronchoalveolar lavage fluid collected during a repeat bronchoscopy were initially identified as Pseudomonas aeruginosa by VITEK-2 and mass spectrometry platforms. Whole-genome sequencing, however, subsequently demonstrated that the bacteria were Pseudomonas nitroreducens, representing the first known case of P. nitroreducens cultured from human lungs.
- infectious diseases
- pneumonia (infectious disease)
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Contributors EO and AH contributed equally to this work. TLT and AH provided concept for manuscript. TLT conducted cytotoxicity experiments. TLT, RW, EO and AH wrote the manuscript. RW and NU SCRIPT investigators provided sample collection. EO conducted genomic analyses. RW, EO and AH provided clinical insight.
Funding This study was funded by National Institute of Allergy and Infectious Diseases (grant numbers: K24 AI104831, R01 AI118257, R21 AI153953 and U19 AI135964).
Competing interests RW, EO and AH report a grant from the National Institute of Allergy and Infectious Diseases during the conduct of the study; U19 AI135964. AH reports grants from the National Institutes of Health during the conduct of the study; R01 AI118257, R21 AI153953 and K24 AI104831.
Provenance and peer review Not commissioned; externally peer reviewed.
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