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Anti-amphiphysin positive stiff-person syndrome due to invasive ductal carcinoma in a male patient
  1. Christopher Connolly1,
  2. Erin Cobain2 and
  3. Tasha Hughes3
  1. 1University of Michigan Medical School, University of Michigan Health System, Ann Arbor, Michigan, USA
  2. 2Department of Medicine, University of Michigan Health System, Ann Arbor, Michigan, USA
  3. 3Department of Surgery, University of Michigan Health System, Ann Arbor, Michigan, USA
  1. Correspondence to Christopher Connolly; connolch{at}


Stiff-person syndrome (SPS) is a rare progressive neurological disorder characterised by painful muscle spasms and progressive muscle rigidity, leading in some cases to impaired ambulation. Anti-amphiphysin positive SPS is a paraneoplastic variant, frequently associated with breast carcinomas and small cell lung cancers. We report the case of a 53-year-old patient who developed symptoms of anti-amphiphysin positive SPS 3 years before being diagnosed with invasive ductal carcinoma. Specifically, computed tomography (CT) of the chest, abdomen and pelvis, positron emission tomography-CT (PET-CT), mammogram, colonoscopy and magnetic resonance imaging (MRI) did not identify malignancy during the 3 years following the onset of symptoms. Following diagnosis of invasive ductal carcinoma and completion of curative-intent oncological treatment, the patient experienced improvement, though not complete resolution, in his SPS symptoms. This case highlights the importance of thorough oncological workup when clinical presentation and diagnostic testing are suggestive of anti-amphiphysin positive SPS.

  • breast cancer
  • movement disorders (other than Parkinsons)
  • breast surgery

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  • Contributors CC: Preparation of manuscript, editing of manuscript, literature review, patient care. TH: Preparation of manuscript, editing of manuscript, patient care. EC: Editing of manuscript, patient care.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.