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Pseudohyponatraemia caused by acute pancreatitis–derived hypertriglyceridaemia
  1. Rasmus Søgaard Hansen1,
  2. Jesper Revsholm1,
  3. Mohammad Motawea2 and
  4. Lars Folkestad2,3
  1. 1Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark
  2. 2Department of Endocrinology, Odense University Hospital, Odense, Denmark
  3. 3Department of Clinical Research, University of Southern Denmark, Odense, Syddanmark, Denmark
  1. Correspondence to Dr Rasmus Søgaard Hansen; rasmussoegaardhansen{at}


We report a case of pseudohyponatraemia due to severe hypertriglyceridaemia-induced acute pancreatitis, stemming from unknown diabetes. A woman in her late 30s was admitted to the local hospital by her general practitioner due to severe hyponatraemia (116 mmol/L) and upper abdominal pain. At admission to the hospital, there was a discrepancy of 19 mmol/L between arterial and venous sodium, along with severe hypertriglyceridaemia and hypercholesterolaemia. Pancreatitis was diagnosed using a CT scan. The patient received plasmapheresis which significantly reduced triglycerides, and venous plasma sodium was normalised indicating pseudohyponatraemia at admission. Finally, a haemoglobin A1c of 83 mmol/mol was found. Diabetes was diagnosed, and insulin was initiated.

  • diabetes
  • pancreatitis

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  • Contributors RSH: Conceptualisation, writing original draft, collected the data, data curation, methodology, performed the systemic search of PubMed and literature review. JFR: Conceptualisation, methodology, critical revision of drafts, laboratory insight and biochemistry angle of the paper. MM: Treated the patient, critical revision of drafts, editing, clinical angle of the paper. LF: Conceptualisation, treated the patient, methodology, critical revision of drafts, editing, idea for figure 1 and table 1, and clinical angle of the paper. All authors approved the submission.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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