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Systemic acitretin in the management of periocular squamous cell carcinoma
  1. Haoyu Wang1,
  2. Bashar Bata1,2,
  3. Zanna Currie1,
  4. Sachin Salvi1,2 and
  5. Jennifer Tan1
  1. 1Ophthalmology Department, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK
  2. 2Oncology and Metabolism, The University of Sheffield, Sheffield, UK
  1. Correspondence to Dr Bashar Bata; bbata{at}


We report a case of periocular squamous cell carcinoma invading the anterior orbit that significantly reduced in size and regressed from invasive to in situ following treatment with oral acitretin, a second-generation retinoid. The residual in situ disease was then successfully treated with cryotherapy and the patient remains in remission 12 months following cessation of systemic acitretin.

  • skin cancer
  • ophthalmology

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  • Contributors We had a request of five authors approved but one of the authors has not been entered into the system as it only allows four. His name is included in the case report template and in the authorship form submitted. HW, BB, ZC, Sachin M Salvi and JT contributed to: conception and design, acquisition of data or analysis and interpretation of data. Drafting the article or revising it critically for important intellectual content. Final approval of the version published. Agreement to be accountable for the article and to ensure that all.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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