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Familial bilateral nodular oncocytic hyperplasia of the parotid gland in mother and son
  1. Yinan Zhu1,
  2. Manuela Cresswell2,
  3. Jonathan Miles Charnock3 and
  4. Philip Reece4
  1. 1ENT, University Hospitals Plymouth NHS Trust, Plymouth, UK
  2. 2ENT, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK
  3. 3Paediatrics, Royal Free London NHS Foundation Trust, London, UK
  4. 4ENT, South Devon Healthcare NHS Foundation Trust, Torquay, UK
  1. Correspondence to Mr Yinan Zhu; yinan.zhu{at}


This case series reports familial cases of nodular oncocytic hyperplasia (NOH) diagnosed in a mother and her son, 15 years apart. A 39-year-old man presented in 2003 with a lump below his left ear. Magnetic resonance imaging (MRI) performed showed multifocal parotid nodules and a diagnosis of NOH was histopathologically confirmed following left total parotidectomy. Two years later, he represented with similar symptoms on the right side. NOH was diagnosed following excision of his right parotid gland. In 2018, his 73-year-old mother presented with left ear pain and a lump below her left ear. An MRI scan showed multiple lesions within both parotid glands and bilateral NOH was once again diagnosed following a left superficial parotidectomy and right total parotidectomy. We believe that this is the first reported case of bilateral familial NOH.

  • ear
  • nose and throat/otolaryngology
  • otolaryngology / ENT

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  • Collaborators Dr Paul Hiley, Consultant Histopathologist at the Cellular Pathology Department in Torbay Hospital for his contribution on providing the histological images and providing advice regarding the cases.

    Mr Simon Hickey, retired Consultant ENT Surgeon for his contribution in reviewing the case report and providing advice regarding the cases.

  • Contributors Case Identification: YZ, MC, JMC and PR; case report: YZ, MC, JC and PR; proofreading: YZ, MC, JMC and PR.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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