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Resolution of hyperthyroidism and thyroid antibodies following struma ovarii resection: an uncommon entity
  1. Preethi Padmanaban1,2,3,
  2. Eric Nylen1,2,
  3. Kenneth Burman4,5 and
  4. Sabyasachi Sen1,2,3
  1. 1Division of Endocrinology, Department of Medicine, The George Washington University, Washington, DC, USA
  2. 2Department of Endocrinology, Washington DC VA Medical Center, Washington DC, DC, USA
  3. 3Division of Endocrinology, Department of Medicine, The Medical Faculty Associates, The George Washington University, Washington DC, DC, USA
  4. 4Department of Medicine, MedStar Washington Hospital Center, Washington, DC, USA
  5. 5Department of Endocrinology, MedStar Georgetown University Hospital, Washington, DC, USA
  1. Correspondence to Dr Sabyasachi Sen; ssen1{at}


We report a case of 34-year-old clinically asymptomatic woman who had been followed for 6 years for hyperthyroidism with thyroid stimulating hormone <0.006 uIU/mL, free T4 1.98 ng/mL, free T3 5.3 pg/mL, elevated thyroid stimulating immunoglobulin 1.70 IU/L, thyroid peroxidase antibody 38 IU/mL and thyroglobulin antibody 9.3 IU/mL. Radioiodine thyroid scan showed minimal uptake in both thyroid lobes (24-hour uptake was 0.3%). She subsequently underwent evaluation for lower abdominal pain and menstrual irregularities, which revealed a large left ovarian cyst measuring 15.9 cm × 10.8 cm × 13.2 cm and right-sided ovarian cyst measuring 2.7 cm × 3.3 cm × 3.5 cm. Laparoscopic bilateral ovarian cystectomy was performed and the final pathology revealed struma ovarii of the left ovarian cyst with the entire ovarian tumour made up of benign thyroid tissue. Thyroid function tests performed 3 months after surgical removal of struma ovarii showed euthyroidism. We present a rare case with detailed laboratory and immunological data before and after ovarian extirpation with resolution of hyperthyroidism associated with functional struma ovarii.

  • thyrotoxicosis
  • thyroiditis
  • thyroid disease
  • obstetrics and gynaecology

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  • Contributors PP was involved in patient care, acquisition of data and drafting of manuscript. EN and KB were involved in revision of manuscript. SS was involved in patient care, revision and final approval of manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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