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Rare case of pancreatic neuroendocrine tumour presenting as paraneoplastic hypercalcaemia
  1. Benjamin Ferrel,
  2. Jan Franko and
  3. May C Tee
  1. Department of Surgical Oncology, MercyOne Medical Center, Des Moines, Iowa, USA
  1. Correspondence to Dr Jan Franko; jfranko{at}


An asymptomatic 68-year-old woman who presented with an isolated hypercalcaemia was diagnosed with a rare, previously unsuspected parathyroid hormone-related peptide (PTHrP)-producing pancreatic neuroendocrine tumour. She underwent an extensive operation including vascular resection and reconstruction, resulting in successful removal of the tumour with negative margins. Medical and surgical management of pancreatic neuroendocrine tumours and PTHrP-mediated paraneoplastic hypercalcaemia is discussed.

  • cancer intervention
  • endocrinology
  • pancreas and biliary tract
  • endocrine cancer
  • surgical oncology

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  • Contributors BF is the primary author and performed the literature review, drafted the manuscript and is overall guarantor of its content. JF assisted in review of the manuscript and is the corresponding author. MT identified and managed the case presented and assisted with review and overall direction of the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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