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Metastatic squamous cell carcinoma of the colon: a conundrum in colorectal malignancies
  1. Sachi Singhal1,
  2. Rohan Bir Singh2 and
  3. Rashmika Potdar3
  1. 1Internal Medicine, Crozer-Chester Medical Center, Upland, Pennsylvania, USA
  2. 2Harvard Medical School, Boston, Massachusetts, USA
  3. 3Crozer-Chester Medical Center, Upland, Pennsylvania, USA
  1. Correspondence to Dr Rohan Bir Singh; dr.rohandhaliwal{at}; Dr Rashmika Potdar; rpotdar{at}


Small-cell carcinoma of the colon is an extremely rare tumour, with poorly understood pathogenesis and unestablished treatment guidelines. The first case was documented in 1919, and only about 100 cases of this condition have been reported to this date. In this case report, we present a case of sigmoid squamous cell carcinoma that eventually led to bowel perforation and was diagnosed on histopathology after emergent surgical intervention. Additionally, we also review the incidence, epidemiology, pathogenesis, immunohistological markers, neogenomics and therapeutic strategies for the same.

  • cancer intervention
  • oncology
  • colon cancer

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  • Contributors RP managed the patient, authored and revised the manuscript. SS and RBS authored and edited the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer-reviewed.

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