Article Text

Download PDFPDF
Post-infectious inflammatory syndrome associated with SARS-CoV-2 in a paediatric patient with Down syndrome
  1. Mellad Khoshnood1,
  2. Roshan Mahabir2,3,
  3. Nick M Shillingford2,3 and
  4. Jonathan D Santoro1,4,5
  1. 1Division of Neurology, Children's Hospital Los Angeles, Los Angeles, California, USA
  2. 2Department of Pathology, Keck School of Medicine at the University of Southern California, Los Angeles, California, USA
  3. 3Department of Pathology, Children's Hospital Los Angeles, Los Angeles, California, USA
  4. 4Department of Pediatrics, Children's Hospital of Los Angeles, Los Angeles, California, USA
  5. 5Department of Neurology, Keck School of Medicine at the University of Southern California, Los Angeles, California, USA
  1. Correspondence to Dr Jonathan D Santoro; jdsantoro{at}


Neurological complications of SARS-CoV-2 continue to be recognised. In children, neurological phenomenon has been reported generally in the acute infectious period. It is possible that SARS-CoV-2 could trigger an immune-mediated post-infectious phenomenon. Here, we present a unique case of post-infectious marantic cardiac lesion causing cerebrovascular accident in a patient with Down syndrome.

  • genetics
  • immunology
  • neuroimaging
  • stroke
  • pathology

This article is made freely available for use in accordance with BMJ’s website terms and conditions for the duration of the covid-19 pandemic or until otherwise determined by BMJ. You may use, download and print the article for any lawful, non-commercial purpose (including text and data mining) provided that all copyright notices and trade marks are retained.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • Contributors The authors listed herein all contributed in a significant way to the creation and submission of this article. MK and JDS identified the case of interest. MK created the initial draft. JDS, MK, RM and NK edited the draft. MK, JDS, RM and NK made further edits and alterations of the draft. RM and NK gathered substantial data, images and information regarding the pathology slides noted above. MK and JDS obtained and reviewed the laboratory values noted above. All authors discussed the findings and contributed to the final manuscript. All authors approved the final draft of this paper.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.