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Tracheobronchopathia osteochondroplastica: a cause of chronic cough and haemoptysis
  1. Talha Shahzad1,
  2. Nadeem Rizvi2,
  3. Sabeeh Siddiqui3 and
  4. Rashida Ahmed4
  1. 1Pulmonary Medicine, The Aga Khan University Hospital, Karachi, Pakistan
  2. 2Pulmonary Medicine, Ziauddin University Hospital, Karachi, Pakistan
  3. 3Pathology, The Aga Khan University Hospital, Karachi, Pakistan
  4. 4Pathology and Microbiology, Aga Khan University, Karachi, Pakistan
  1. Correspondence to Dr Talha Shahzad; talha.shahzad{at}


Tracheobronchopathia osteochondroplastica (TPO) is a rare disorder of the tracheopulmonary tree characterised by osseous and cartilaginous submucosal nodules projecting into the tracheal lumen, sparing the posterior tracheal membranous wall. Symptoms are non-specific and may include dry cough, hoarseness, dyspnoea, recurrent pneumonia and occasionally haemoptysis. A fibreoptic bronchoscopy showing multiple tracheal nodules followed by pathological biopsy is required to reach the final diagnosis. Here, we report two cases of TPO, both with history of biomass fuel exposure and almost similar clinical presentions with chronic cough, shortness of breath and intermittent haemoptysis. They both underwent fibreoptic bronchoscopy showing multiple tracheal nodules whose histopathological analysis showed the diagnosis of TPO. Both patients were treated conservatively and remained in good health afterwards. Physicians should be aware about the need of advanced surgical procedures including endotracheal stent placement in more severe cases.

  • respiratory system
  • pneumonia (respiratory medicine)
  • bronchitis

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  • Contributors TS and RA accept full responsibility for the work. TS and NR had the original idea. SS and TS did the literature search and wrote the article. Case 1 was identified by TS, RA and SS. Case 2 was identified by NR and RA. SS and RA provided the histopathology images.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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