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Tale of two viruses: parvovirus B19 and HIV
  1. Hayley Hernstadt1,2,
  2. Paul Randell3,
  3. Sarah Fidler3 and
  4. Caroline Foster1
  1. 1Department of Paediatric Infectious Diseases, Imperial College Healthcare NHS Trust, London, UK
  2. 2Department of Paediatrics, Monash University, Melbourne, VIC, Australia
  3. 3Department of Infectious Diseases, Imperial College Healthcare NHS Trust, London, UK
  1. Correspondence to Dr Hayley Hernstadt; hayleyhernstadt{at}


We present a HIV-infected patient who developed severe anaemia due to chronic parvovirus B19 infection and subsequently had an unplanned pregnancy. This is in the context of poor adherence to antiretroviral therapy and significant immunosuppression; there was a delay in diagnosis of chronic parvovirus infection due to attribution of anaemia to HIV. She received immunoglobulin therapy and effective antiretroviral therapy, with reduction in parvovirus load and improvement in anaemia. She was counselled regarding the need for monitoring in pregnancy due to risk of intrauterine infection. We review the literature of management of chronic parvovirus infection in the immunosuppressed and the consequences of intrauterine infection.

  • haematology (incl blood transfusion)
  • HIV / AIDS
  • infectious diseases
  • materno-fetal medicine

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  • Contributors CF and PR conceptualised the article. HH was the primary author. All authors participated in the editing process. All authors provided substantial contributions to the final manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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