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Acute lung toxicity by nitrofurantoin
  1. Eliana Milazzo1,
  2. Gabriela Orellana1,
  3. Adriana Briceño-Bierwirth1 and
  4. Vamsi Kiran Korrapati2
  1. 1Department of Internal Medicine, Texas Tech University Health Sciences Center School of Medicine, Odessa, Texas, USA
  2. 2Department of Internal Medicine, Midland Inpatient Medical Associates, Midland Memorial Hospital, Midland, Texas, USA
  1. Correspondence to Dr Eliana Milazzo; Eliana.milazzo{at}


Nitrofurantoin is a synthetic derivative of imidazolinedione, used to treat uncomplicated urinary tract infections. It acts by inhibiting bacterial DNA, RNA and cell wall protein synthesis. It is used prophylactically as a urinary anti-infective agent against most gram-positive organism and for long-term suppression of infections. Nitrofurantoin-associated pulmonary injuries occur in 1% of patients, presenting with dyspnoea and dry cough, and it can mimic interstitial lung disease. We present a case of an 81-year-old woman with shortness of breath and cough 3 days after initiation of nitrofurantoin. CT of the chest revealed bilateral pleural effusion and extensive pulmonary interstitial prominence, suggesting pulmonary fibrosis. According to the Naranjo Adverse Drug Reaction Probability Scale score of 6, it was determined that nitrofurantoin was the probable cause, and immediate cessation of the medication showed a marked clinical improvement and resolution after 10 days.

  • respiratory system
  • unwanted effects / adverse reactions

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  • Contributors Summary and treatment: VKK. Background, investigations, outcome and follow-up: AB-B. Case presentation: EM. Differential diagnosis: GO. Discussion and learning points/take-home messages: EM and GO.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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