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Case report
Pemphigoid gestationis: a rare pregnancy dermatosis treated with a combination of IVIg and rituximab
  1. Arunachalam Narayanan1,
  2. Rashi Pangti1,
  3. Shipra Agarwal2 and
  4. Neetu Bhari1
  1. 1Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India
  2. 2Pathology, All India Institute of Medical Sciences, New Delhi, India
  1. Correspondence to Dr Neetu Bhari; drntbhari{at}gmail.com

Abstract

Pemphigoid gestationis is a rare autoimmune subepidermal bullous dermatosis occurring during pregnancy and post partum. A 32-year-old woman developed itchy urticarial wheals over the trunk and extremities at 6 months of gestation. This was not controlled with antihistamines, and 2 months later, the patient developed multiple vesiculobullous lesions. The patient had an exacerbation 3 weeks post-delivery. She did not go into remission for 6 months post partum despite treatment with prednisolone 40 mg/day, doxycycline 100 mg two times per day and dapsone 100 mg/day. The patient went into remission following treatment with three courses of intravenous immunoglobulin 2 mg/kg/course and 2 doses of rituximab 1 g at a 2-week interval.

  • dermatology
  • pregnancy

https://doi.org/10.1136/bcr-2020-241496

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    Footnotes

    • Contributors All authors have contributed substantially and sufficiently to the data collection and completion of this article. AN: Data collection and compilation (patient management), writing and reporting the paper. RP: Data collection and writing the paper. SA: Data collection (histopathology) and writing the paper. NB: Conception and conduct of the report, supervising and writing the paper.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Patient consent for publication Obtained.

    • Provenance and peer review Not commissioned; externally peer reviewed.