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MALT lymphoma and eosinophilic oesophagitis: incidental finding— review of possible factors influencing the aetiopathogenesis of eosinophilic oesophagitis
  1. Beatriz Fernandez Manso,
  2. Josefa Barrio Torres,
  3. Beatriz Martinez Escribano and
  4. Cristina Perez Fernandez
  1. Pediatric Department, Hospital Universitario de Fuenlabrada, Fuenlabrada, Madrid, Spain
  1. Correspondence to Beatriz Fernandez Manso; bfmanso_ped{at}hotmail.com

Abstract

An 11-year-old boy with a history of atopy and allergic rhinitis under treatment with sublingual immunotherapy was referred following several episodes of food impaction. Diagnosis of eosinophilic oesophagitis, chronic gastritis and gastric mucosa-associated lymphoid tissue (MALT) lymphoma associated to Helicobacter pylori were confirmed. Results of the extension study were negative and the lymphoma was resolved with eradicating treatment for H. pylori. No improvement was observed in the oesophagitis after the withdrawal of immunotherapy and treatment with high proton pump inhibitor doses or following the omission of several foods to which subclinical sensitisation was confirmed. Oesophagitis was finally resolved by removing cow's milk protein. After 10 years, neither eosinophilic oesophagitis nor MALT lymphoma was observed.

Gastric MALT lymphoma associated to H. pylori is a rare disorder in children. Although coexisting H. pylori infection is common in patients with eosinophilic oesophagitis, the association of gastric MALT lymphoma with eosinophilic oesophagitis has not been reported before.

  • helicobacter pylori
  • oesophagus
  • endoscopy
  • gastric cancer
  • paediatrics

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Footnotes

  • Twitter @jbarrio.hflr@gmail.com

  • Contributors BFM and JBT have made substantial contributions to the conception and design of the work. BME and CPF have revised it critically for important intellectual content. BFM, JBT, BME and CPF have contributed to the final approval of the version to be published and they agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Parental/guardian consent obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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