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Case report
Antiphospholipid syndrome leading to paradoxical embolus and stroke via secundum atrial septal defect
  1. Amy Campbell1,
  2. Avinash Kumar Kanodia2,
  3. Christopher Robert Gingles3 and
  4. Harinath Chandrashekar4
  1. 1Emergency Department, NHS Tayside, Dundee, UK
  2. 2Radiology, Ninewells Hospital and Medical School, Dundee, UK
  3. 3Cardiology, University of Dundee, Dundee, UK
  4. 4Stroke Medicine, NHS Tayside, Dundee, UK
  1. Correspondence to Dr Avinash Kumar Kanodia; avinash.kanodia{at}nhs.scot

Abstract

We have presented a case of a 22-year-old man, presenting with cerebral infarct, subsequently found to have antiphospholipid syndrome (APS), deep venous thrombosis, pulmonary embolism and atrial septal defect (ASD), thereby confirming the presence of infarct due to paradoxical embolism in this patient. The importance of ASD in the patients of APS, resulting in paradoxical embolism is debatable, with recent studies undermining its importance. We have demonstrated that it does indeed happen. This would have implications in the risk assessment and management of ASD in such patients. This case report is intended to serve as a reminder of this association and the need to perform further research in this area.

  • stroke
  • interventional cardiology

https://doi.org/10.1136/bcr-2020-239674

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    Footnotes

    • Contributors I confirm that all authors (AC, AKK, CRG, HC) have made significant contributions to the manuscript. All authors (AC, AKK, CRG, HC) have contributed to planning, conduct, reporting, conception and design, acquisition of data or analysis and interpretation of data and so on. All authors (AC, AKK, CRG, HC) have read and approved the final manuscript.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Patient consent for publication Obtained.

    • Provenance and peer review Not commissioned; externally peer reviewed.