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Extramedullary relapse of multiple myeloma presenting as a breast lump
  1. Dale Seviar1,
  2. Zainab AlshiekhAli2 and
  3. David Howlett3
  1. 1Haematology Department, Eastbourne District General Hospital, East Sussex, UK
  2. 2Pathology Department, Eastbourne District General Hospital, Eastbourne, UK
  3. 3Radiology, Eastbourne District General Hospital, Eastbourne, UK
  1. Correspondence to Dr Dale Seviar; dale.seviar{at}


Multiple myeloma (MM) involving the breast tissue is rare. We report the case of a 70-year-old woman with a background of previously treated MM in remission presenting with a breast lump. Histology showed a plasma cell neoplasm and subsequent staging investigations showed widespread extramedullary relapse of MM. Despite its rarity, this diagnosis should be considered within the differential diagnosis of breast masses as it can arise de novo or may be the first presenting feature of myeloma. The importance of the multidisciplinary team approach with triple assessment of the breast, as well as recent advances in knowledge regarding extramedullary disease in myeloma and novel treatment approaches in MM are discussed.

  • haematology (incl blood transfusion)
  • breast cancer
  • chemotherapy
  • pathology
  • radiology

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  • Contributors DS: wrote up the case report and the discussion. ZA: provided histolopathology images, report and figure legends. DH: provided radiology images and expert editing of material.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.