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Systemic lupus erythematosus multiorgan flare with quiescent serologic markers
  1. Jennifer Jane Gile1,
  2. Jaskanwal Deep Singh Sara2 and
  3. Michael R Mueller1
  1. 1Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA
  2. 2Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA
  1. Correspondence to Dr Jennifer Jane Gile; Gile.Jennifer{at}


Systemic lupus erythematosus (SLE) can affect almost every organ with differing degrees of severity. Typically, SLE activity is associated with hypocomplimentaemia and elevated double-stranded DNA (dsDNA) levels. We describe a case of a severe multiorgan lupus flare including lupus cerebritis, autoimmune haemolytic anaemia, lupus nephritis and lupus myopericarditis with normal complement and dsDNA levels. This highlights the importance of understanding the heterogeneous nature of SLE flares.

  • systemic lupus erythematosus
  • rheumatology

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  • Contributors JJG, JDSS and MM contributed to the care of the patient and to the writing of the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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