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Addison’s disease with primary hypothyroidism in a case of visceral leishmaniasis and HIV coinfection
  1. Monu Rani,
  2. Rakesh Garg,
  3. Venkatesh Darshan Agraharabachalli Nanjunde and
  4. Rajesh Rajput
  1. Department of Endocrinology and Medicine, Pandit Bhagwat Dayal Sharma Postgraduate Institute of Medical Sciences, Rohtak, India
  1. Correspondence to Dr Rajesh Rajput; drrajeshrajput{at}


A 41-year-old man presented with vomiting and loose stools. He had a history of long-term intermittent fever, generalised skin hyperpigmentation, dragging sensation in the left hypochondrium and unintentional weight loss. He was receiving combination antiretroviral therapy since 2010 for HIV infection. He also received antitubercular therapy for tuberculous spondylitis. During the hospital stay, he was found to have postural hypotension, hypoglycaemia, hyponatraemia, hyperkalaemia, pancytopenia, hypothyroidism, hyperglobulinaemia and hypoalbuminaemia with reversal of serum albumin/globulin ratio. The morning plasma cortisol was lower than normal and could not be appropriately stimulated after the Synacthen test. The bone marrow histopathology was suggestive of visceral leishmaniasis. He was diagnosed as a case of visceral leishmaniasis and HIV coinfection with primary adrenal insufficiency (Addison’s disease) and primary hypothyroidism, as a rare and unusual presentation.

  • HIV / AIDS
  • adrenal disorders
  • endocrine system
  • haematology (drugs and medicines)

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  • Contributors RR conceived the idea of the case report and provided the scientific guidance for the case workup. MR has worked with the case investigations, acquisition and interpretation of the data. MR, RG and VDAN have worked for drafting and reporting the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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