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Takayasu’s arteritis and secondary membranous nephropathy: an exceptional association
  1. Daniel Enos1,2,3,
  2. Gonzalo Labarca2,4,
  3. Mariel Hernandez3 and
  4. Gonzalo P Mendez5
  1. 1Internal Medicine, Universidad San Sebastian, Los Ángeles, Chile
  2. 2Internal Medicine, Complejo Asistencial Dr. Victor Rios Ruiz, Los Angeles, Chile
  3. 3Nephrology Unit, Complejo Asistencial Dr. Victor Rios Ruiz, Los Angeles, Chile
  4. 4Internal Medicine, Universidad de Concepcion, Los Angeles, Chile
  5. 5Anatomia Patologica, Pontificia Universidad Catolica de Chile, Santiago, Chile
  1. Correspondence to Dr Gonzalo Labarca; glabarcat{at}gmail.com

Abstract

The association between Takayasu’s arteritis and membranous nephropathy is uncommon. We present the case of a 46-year-old man with Takayasu’s arteritis treated over 10 years by a multidisciplinary medical team. He had an atrophic left kidney due to arterial stenosis, with a basal creatinine of 1.59 mg/dL (140.55 µmol/l). Three years ago, he presented with full nephrotic syndrome, uncontrolled blood pressure, creatinine increases to 4.5 mg/dL (basal: 1.59 mg/dL), severe hypoalbuminaemia (1.4 g/dL) and albuminuria of 24.6 g per day. He underwent percutaneous biopsy of the right kidney that showed membranous nephropathy with negative PLA2R1 and positive IgG 1, 3 and 4 subclasses. After therapy with oral prednisone and cyclophosphamide, the patient’s kidney function improved, without recurrence of disease after 3 years of follow-up. Here, we present this extremely uncommon association of Takayasu’s arteritis and membranous nephropathy.

  • nephrotic syndrome
  • chronic renal failure
  • vasculitis

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Footnotes

  • Contributors DE: principal investigator, data acquisition, data synthesis, critical analysis, English manuscript redaction and final approval. GL: data synthesis, critical analysis, manuscript redaction and final approval. MH: literature revision, critical analysis and final approval. GPM: biopsy sample interpretation, literature revision, critical analysis and final approval. All authors read and approved the final manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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