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Monoclonal gammopathy of undetermined significance (MGUS) manifestation in CNS: a regular or chance occurrence?
  1. Lidiia Prakhova,
  2. Valeriy Lebedev,
  3. Aleksandr Ilves and
  4. Yulia Nazinkina
  1. N.P. Bechtereva Institute of the Human Brain of the Russian Academy of Sciences, Saint-Petersburg, Russian Federation
  1. Correspondence to Dr Lidiia Prakhova; l.n.prakhova{at}


Monoclonal gammopathy of undetermined significance (MGUS)-associated involvement of the peripheral nervous system is widely reported in the literature. At the same time, involvement of central nervous system (CNS) occurs far less frequently. Analysing the reported cases, almost all the authors pose the question whether there is a relationship between CNS involvement and MGUS, and at what stage it is necessary to begin therapy of haematological disorders. The limited number of reported cases precludes us from getting a definite answer to these questions, thus making further accumulation of clinical data highly relevant. In this article, we present two cases of CNS involvement in patients with MGUS, which, in our opinion, may suggest the existence of a causal relationship between MGUS and CNS involvement. Currently, the above hypothesis cannot be taken as proved due to the lack of a sufficient number of clinical observations and scientific studies. Therefore, the issue of MGUS-associated CNS involvement requires further research.

  • monoclonal gammopathy of undetermined significance associated neuropathy
  • haematology (incl blood transfusion)
  • neurology
  • monoclonal gammopathy of undetermined significance
  • central nervous system
  • neurology

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  • Contributors VL and AI processed all available data and were the major contributors in writing the manuscript. YN processed and described MRI data. LP directly oversaw the patients and revised the manuscript. All authors have read and approved the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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