Article Text

Download PDFPDF
Ophthalmic anterior segment metastasis masquerading as uveitis
  1. Quang Le Nguyen1,
  2. Samuel Benjamin Reynolds1,
  3. Niloofar Piri2 and
  4. Hiram L Rivas Perez1
  1. 1Department of Internal Medicine, University of Louisville School of Medicine, Louisville, Kentucky, USA
  2. 2Ophthalmology, University of Louisville School of Medicine, Louisville, Kentucky, USA
  1. Correspondence to Dr Quang Le Nguyen; quang.nguyen{at}


Ocular malignancies are rare, with many cancers of the eye being the result of metastases, the most common of which result from primary tumours of breast, lung and gastrointestinal tract. Diagnosis is often made at a late stage in the disease course, leading to poorer outcomes. Disease-directed therapy in the presence of ocular metastases varies based on the primary tumour and patient performance status but generally involves systemic treatment, either with chemotherapy or involved-field radiation. We herein present an interesting case of ocular malignancy with neuroendocrine small cell features of pulmonary origin in a patient with no prior oncological history. Meticulous ophthalmic examination led to the diagnosis of small cell lung carcinoma with anterior segment metastasis. The patient underwent six cycles of systemic chemotherapy with a favourable response, resulting in improvement in vision and regression of the ocular lesion.

  • cancer intervention
  • eye
  • lung cancer (oncology)
  • anterior chamber

Statistics from


  • Contributors QLN, SBR and NP wrote the manuscript, drafting and revising it critically for important intellectual content. QLN, SBR and NP contributed to the final version of the manuscript. HLRP provided critical feedback and was involved in the final approval of the version to be published.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.