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A rare emergence of resistance to ceftolozane/tazobactam in Klebsiella pneumoniae causing urinary tract infection
  1. Antony Arumairaj1,
  2. Sanket Agarwal1,
  3. Tarun Popli2 and
  4. Eliana Lopez2
  1. 1Internal Medicine, Metropolitan Hospital Center, New York, New York, USA
  2. 2Infectious Disease, Metropolitan Hospital Center, New York, New York, USA
  1. Correspondence to Dr Antony Arumairaj; antojack99{at}


The management of infections caused by carbapenem-resistant organisms has been a challenge. We report a rare emergence of resistance to the novel beta-lactam/ beta-lactamase combination ceftolozane/tazobactam by Klebsiella pneumoniae, causing urinary tract infection. The K. pneumoniae, in this case, was reported to be sensitive to the other novel beta-lactam/ beta-lactamase combination of ceftazidime/avibactam. The timely administration of ceftazidime/avibactam resulted in prompt clinical resolution of the urinary tract infection caused by an extensively drug-resistant K. pneumoniae.

  • urinary tract infections
  • therapeutic indications
  • global health
  • drugs: infectious diseases

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  • Contributors Planning, conduct, reporting, conception, design, data collection, data analysis, data interpretation, drafting the article, critical revision of the article, final approval of the version to be published: All authors.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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