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Rare paraneoplastic syndromes in digestive systems caused by lung cancer
  1. Hiroteru Kamimura1,
  2. Tomohiro Iwasaki2,
  3. Kazunao Hayashi1 and
  4. Shuji Terai1
  1. 1Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences Niigata University, Niigata, Japan
  2. 2Tsubame Rosai Hospital, Tsubame, Japan
  1. Correspondence to Dr Hiroteru Kamimura; hiroteruk{at}


We observed a rare case of two different digestive paraneoplastic syndromes that improved with the treatment of the neoplasms. The first syndrome was chronic intestinal pseudo-obstruction (CIPO), which is a subtype of paraneoplastic syndromes called a paraneoplastic neurological syndrome (PNS). The second was Stauffer’s syndrome, which is a unique paraneoplastic syndrome characterised by non-metastatic intrahepatic cholestasis associated with neoplasms. Here, we report the case of a 55-year-old man who presented with two concurrent paraneoplastic syndromes in the digestive system. The intestinal pseudo-obstruction and elevated biliary enzyme levels improved as the lung cancer responded to chemotherapy. In this case, CIPO as a PNS led to the detection of lung cancer. To our knowledge, this is the first report of Stauffer’s syndrome caused by lung adenocarcinoma.

  • neurogastroenterology
  • lung cancer (oncology)
  • neurooncology

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  • Contributors HK, TI, KH and ST were responsible for the organisation and coordination of the case report.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Parental/guardian consent obtained.

  • Provenance and peer review Not commissioned; externally peer-reviewed.