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IgG4-related disease: a great mimicker of lung cancer
  1. Natalie Louise Simon and
  2. Mostafa Negmeldin
  1. Respiratory Medicine Department, Bedford Hospital, Bedfordshire Hospitals NHS Foundation Trust, Bedford, Bedfordshire, UK
  1. Correspondence to Dr Natalie Louise Simon; natalie.simon2{at}


IgG4-related disease is a rheumatological disorder, affecting multiple organ systems, and displaying dense lymphoplasmacytic inflammatory infiltrate and storiform fibrosis on histology. The pulmonary manifestations of IgG4-related disease are varied. Most commonly, bronchovascular consolidation and perilymphatic parenchymal thickening occur. IgG4-related disease can present as a solitary parenchymal mass and is often mistaken for a primary pulmonary or haematological malignancy. This report presents a case of IgG4-related disease in a patient with 6 months reported haemoptysis symptomatology and CT findings of perihilar lymphadenopathy, multiple pulmonary parenchymal nodules and a single parenchymal mass. Clinician cognisance of the histopathological presentation of IgG4-disease is important. It should be considered as a differential in patients for which investigations have ruled out malignancy, as it is responsive to glucocorticoids in the majority of cases.

  • interstitial lung disease
  • lung cancer (oncology)
  • respiratory system

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  • Contributors This case report was written by Dr Natalie Simon and Dr Mostafa Negmeldin.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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