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Reversible, severe mitral regurgitation in thyrotoxic Graves’ disease
  1. Kaveh Fekri1,
  2. Caroline Maud Michel2 and
  3. Michael Tamilia3
  1. 1Internal Medicine, McGill University, Montreal, Québec, Canada
  2. 2Division of Cardiology, McGill University, Montreal, Québec, Canada
  3. 3Endocrinology and Metabolism, Sir Mortimer B Davis Jewish General Hospital, Montreal, Québec, Canada
  1. Correspondence to Dr Kaveh Fekri; kaveh_fk83{at}


Mitral valve prolapse is a common finding in Graves’ disease. However, severe mitral regurgitation (MR) is a relatively uncommon manifestation of Graves’ disease. We report a case of a 32-year-old woman with toxic Graves’ disease and MR. The echocardiogram was suggestive of severe MR with biventricular failure, severe enough to be considered for mitral valve replacement. With medical control of the thyrotoxic state, a repeat echocardiogram revealed only trace MR, with normal left ventricular function. The timely management of the thyrotoxic state in this patient with Graves’ disease and moderate to severe MR possibly related to myxomatous degeneration, averted the need for mitral valve replacement.

  • hyperthyroidism
  • thyrotoxicosis
  • valvar diseases

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  • Contributors KF collected data for case writing, did the literature review and contributed to manuscript writing. CMM reviewed and captured the echocardiographic images and videos, and reviewed and edited the manuscript. MT contributed to manuscript writing and reviewed the final manuscript before submission.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.