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Unclassifiable lymphoma in pregnancy
  1. Mariola Hernández Martínez1,2,
  2. César Lizán Tudela1,2 and
  3. Ana Saus Carreres3
  1. 1Obstetrics and Gynecology Department, Hospital Clínico Universitario, Valencia, Comunitat Valenciana, Spain
  2. 2Pediatrics, Obstetrics and Gynecology Department, Universitat de Valencia Facultat de Medicina i Odontologia, Valencia, Comunitat Valenciana, Spain
  3. 3Hematology Department, Hospital Clínico Universitario, Valencia, Comunitat Valenciana, Spain
  1. Correspondence to Mariola Hernández Martínez; mariolahermar{at}


A 28-year-old woman, 15 weeks pregnant, consulted for cervical ache and left laterocervical mass. Imaging scans revealed a large mediastinal mass that had spread to supraclavicular and left axillar spaces, including cervicobrachial plexus. Pathological anatomy confirmed an unclassifiable lymphoma, with intermediate features between diffuse large B-cell lymphoma and classical Hodgkin’s lymphoma. CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) therapy was started with partial response. But due to disease progression, an elective caesarean section was performed (30th week of pregnancy) to begin a chemotherapy regime incompatible with pregnancy. Despite acute complications related to prematurity, the newborn could be discharged from hospital at 45 days of life. The patient did not respond to the second treatment line and she is currently undergoing a third chemotherapy regime. Given the unusual occurrence of lymphoma during pregnancy, multidisciplinary teamwork between haematologists, neonatologists and obstetricians is essential to achieve the best maternal–fetal outcome.

  • haematology (drugs and medicines)
  • pregnancy
  • neonatal and paediatric intensive care

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  • Contributors MHM, corresponding author, has been responsible for developing the case (selection, follow-up, investigation, research, documentation and review of the topic). CLT, as a more experienced doctor, has been supervising and making corrections of the work. ASC, as an specialist in haematology, has been in charge of reviewing the case report from the point of view of her field.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.