Article Text

Download PDFPDF
Primary versus secondary nature of mesenteric neuroendocrine tumours
  1. Ariel Park1,
  2. Alicia Martin1,
  3. Ramos Carlos2 and
  4. Vladimir Neychev3
  1. 1University of Central Florida College of Medicine, Orlando, Florida, USA
  2. 2Department of Pathology, Central Florida Regional Hospital, Sanford, Florida, USA
  3. 3Department of Clinical Sciences, University of Central Florida College of Medicine, Orlando, Florida, USA
  1. Correspondence to Dr Vladimir Neychev; Vladimir.Neychev{at}


Neuroendocrine tumours (NETs) are rare group of malignancy that originate from neuroendocrine cells present throughout the body. Most patients with NET first present with symptoms associated with metastasis, and up to 20% of patients have unknown primary site of tumour. Most common metastatic sites for small intestine NETs (SI-NETs) are the locoregional lymph nodes and liver. Although mesenteric metastasis through direct extension or lymphatic spread from SI-NETs is common, mesenteric extranodal involvement is extremely rare, and its biology and primary versus secondary nature are not well understood. Due to their small size and location, SI-NETs are frequently undetected on anatomical imaging or indium-111-pentetreotide single-photon emission computed tomography/CT (Octreoscan) and are difficult to be found via endoscopy. Gallium-68-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-octreotate positron emission tomography (68Ga-DOTATATE PET)/CT has been increasingly used for accurate staging, unknown primary tumour site localisation and appropriate management planning. We present a case of an incidentally found mesenteric NET with occult SI-NETs localised preoperatively by 68Ga-DOTATATE PET/CT.

  • endocrine cancer
  • surgery
  • gastrointestinal surgery
  • general surgery
  • surgical oncology

Statistics from


  • Contributors AP: data acquisition, data analysis and interpretation and drafting of the manuscript. AM: data acquisition and data analysis and interpretation. RC: data analysis and interpretation and critical revision of the manuscript. VN: study concept and design, data acquisition, data analysis and interpretation, drafting of the manuscript and critical revision of the manuscript for important intellectual content.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.