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Case report
Multiple enlarging hepatic and retroperitoneal myelolipomas in the setting of Cushing disease
  1. Grace G Zhu1,
  2. Benjamin L Witt2,
  3. Thomas C Winter III1 and
  4. Douglas M Rogers1
  1. 1Department of Radiology, University of Utah Health, Salt Lake City, UT, USA
  2. 2Department of Anatomical Pathology, University of Utah Health, Salt Lake City, UT, USA
  1. Correspondence to Dr Thomas C Winter III; tom.winter{at}utah.edu

Abstract

Myelolipomas are benign tumours typically occurring in the adrenal glands, made up of fat and trilineage haematopoeitic cells resembling bone marrow. Their aetiology is not well understood; however, they have a clear association with elevated serum adrenocorticotropic hormone (ACTH). Extra-adrenal myelolipomas are rare, and to our knowledge there are no previously reported cases of multiple enlarging hepatic and retroperitoneal myelolipomas in the setting of Cushing disease. We present the case of a patient with an ACTH-producing pituitary adenoma who developed multiple enlarging fat containing lesions in the liver and retroperitoneum, which were histologically proven multifocal myelolipomas.

  • radiology
  • pituitary disorders
  • pathology
  • medical management

https://doi.org/10.1136/bcr-2020-239107

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    Footnotes

    • Contributors GGZ: contributed to manuscript. BLW: provided consultation on pathology and reviewed manuscript. TCWIII: revised and reviewed manuscript. DMR: trailing author/contributed to manuscript.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests DMR discloses personal fees for written work from Elsevier, which is unrelated to the current body of work.

    • Patient consent for publication Obtained.

    • Provenance and peer review Not commissioned; externally peer reviewed.