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Polyangiitis overlap syndrome: a novel presentation of microscopic polyangiitis and eosinophilic granulomatosis with polyangiitis
  1. Nidaa Rasheed1,2,
  2. Rahul Ahuja2 and
  3. Hena Borneo2
  1. 1Saint George's University School of Medicine, Saint George, Grenada
  2. 2Internal Medicine, Highland Hospital, Oakland, California, USA
  1. Correspondence to Nidaa Rasheed; nrasheed{at}


Polyangiitis overlap syndrome (POS) is a diagnostic term coined by Leavitt and Fauci that characterises patients with overlapping features of more than one vasculitis. Prior case studies of antineutrophil cytoplasmic antibodies (ANCA)-associated POS have only been published in patients with eosinophilic granulomatosis with polyangiitis (EGPA) and granulomatosis with polyangiitis alongside proteinase-3/cytoplasmic (C)-ANCA positivity. We present a case of a 60-year-old woman with dyspnoea, hemoptysis, positive perinuclear-ANCA and renal biopsy demonstrating evidence of microscopic polyangiitis. In addition, our patient also had asthma, mononeuritis multiplex, eosinophilia and migratory pulmonary infiltrates, thus fulfilling the criteria for EGPA. This novel case report suggests that POS is not limited to C-ANCA positivity and has variable presentations.

  • vasculitis
  • cardiovascular medicine
  • drugs and medicines

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  • Contributors NR conceived the presented idea and wrote the manuscript with RA. RA obtained consent and prior patient history from other healthcare providers. HB supervised and contributed to the final version of the manuscript, and obtained corresponding images.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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