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Idiopathic hypertrophic cranial polyneuropathy: a rare cause of orbital pain
  1. Palaniraj Rama Raj1,2,
  2. Himeesh Kumar2,
  3. Jerome Ha2 and
  4. Sue Ling Wan1,2
  1. 1Discipline of Clinical Ophthalmology and Eye Health/Save Sight Institute, The University of Sydney, Sydney, New South Wales, Australia
  2. 2Department of Ophthalmology, Parke Street Specialist Centre, Katoomba, New South Wales, Australia
  1. Correspondence to Dr Palaniraj Rama Raj; palaneraj{at}


Hypertrophic cranial polyneuropathy (HCP) is sporadically encountered in clinical practice. Aetiologies of HCP have been classified as autoimmune, infectious and demyelinating. However, an accurate diagnosis remains elusive in some cases despite rigorous investigations. These cases represent idiopathic HCP. Given the high clinical variance in presenting symptoms, HCP often leaves medical practitioners in a diagnostic quandary. Here, we seek to expand current knowledge by reporting the first documented case of idiopathic HCP presenting atypically with unilateral orbital pain and exclusively involving the bilateral trigeminal nerves.

  • ophthalmology
  • neuroimaging
  • cranial nerves
  • radiology

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  • Contributors PRR and HK acquired the clinical data and drafted the work. JH and SLW critically revised and approved the final published version. PRR was primarily responsible for manuscript preparation.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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