Article Text
Abstract
A male infant, born preterm at 32 weeks of gestation, was referred at 36-week postmenstrual age for retinopathy of prematurity (ROP) screening. He had nystagmus, generalised hypopigmentation of skin, hair and eyes with preaxial polydactyly. The fundus was depigmented with prominently visible choroidal vessels. The retinal vessels were dilated, tortuous at zone 1. There was presence of arcading, shunting of vessels with presence of vitreous haemorrhage in the left eye. A diagnosis of aggressive posterior retinopathy of prematurity (APROP) in association with oculocutaneous albinism (OCA) was made.
Half-dose intravitreal bevacizumab was used to treat the vascular condition. After 2 weeks, there was complete regression of APROP with a completely mature retina observed at 4 months post-treatment. Herein, we describe the role of red-free light for screening ROP in infants with OCA; challenges in the management of ROP with laser photocoagulation compared with intravitreal anti-vascular endothelial growth factor therapy.
- retina
- ophthalmology
- paediatrics
- congenital disorders
- neonatal and paediatric intensive care
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Footnotes
Twitter @bhavikpanchal87
BP and MG contributed equally.
Contributors MG: initial preparation of the entire manuscript and compilation of contributions from other authors, and reviewed the requirements and guidelines for submission, and designed the template accordingly. BP: contributed to establishing the diagnosis and management of the patient as a retina consultant, an extensive literature search of similar cases, writing the case presentation, revision of the manuscript, citation management, and editing of images, set up the timeline for submission, planning the submission to BMJ, reviewed the requirements, critical revision of the article at every stage, drafted the take-home messages and gave final approval of the version to be submitted.
Funding This study was funded by the Hyderabad Eye Research Foundation (BHR-R-12-20-572).
Competing interests None declared.
Patient consent for publication Parental/guardian consent obtained.
Provenance and peer review Not commissioned; externally peer reviewed.