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Localised laryngotracheal amyloidosis: a differential diagnosis not to forget
  1. Catarina Mira1,
  2. Pedro Montalvão2,
  3. Isabel Fonseca3 and
  4. Alexandra Borges4
  1. 1Radiology Department, Hospital Beatriz Angelo, Loures, Portugal
  2. 2Otorhinolaryngology Deparment, Portuguese Institute of Oncology of Lisbon, Francisco Gentil, Lisbon, Portugal
  3. 3Pathology, Portuguese Institute of Oncology of Lisbon, Francisco Gentil, Lisboa, Portugal
  4. 4Radiology Department, Portuguese Institute of Oncology of Lisbon, Francisco Gentil, Lisboa, Portugal
  1. Correspondence to Dr Alexandra Borges; borgalexandra{at}


We present a case of multifocal laryngotracheal amyloidosis (LTA) in a 43-year-old man with persistent and progressive dysphonia and dyspnoea, and a first inconclusive histology. Although laryngeal amyloidosis accounts for fewer than 1% of all benign laryngeal tumours, it is in fact the most common site of amyloid deposition in the head, neck and respiratory tract. The clinical scenario is non-specific and diagnosis depends on a high degree of suspicion and on histology. Imaging is useful in mapping lesions, which are often more extensive than they appear during laryngoscopy. Despite being a benign entity, the prognosis is variable with a high-rate and long-latency recurrences, requiring long-term follow-up.

  • ear
  • nose and throat/otolaryngology
  • pathology
  • radiology
  • otolaryngology / ENT

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  • Contributors The first author, CM, was the main writer of the article, responsible also for the bibliographical research. The second author, IF, was responsible for searching the pathology images, as well giving an adequate legend. The third author, PM, was responsible for the laryngoscopy images. The final author, AB, was the coordinator and final reviewer of all the content of this article.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.