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Squamous cell carcinoma at the site of ileo-anal pouch in Crohn’s disease
  1. Dorina Gabriela Condurache1,
  2. Jonathan P Segal1,
  3. Ailsa L Hart2 and
  4. Anthony Antoniou3
  1. 1Gastroenterology, London North West University Healthcare NHS Trust, Harrow, London, UK
  2. 2Gastroenterology, St Mark's Hospital and Academic Institute, Harrow, London, UK
  3. 3St Mark's Hospital Foundation, Harrow, London, UK
  1. Correspondence to Dr Dorina Gabriela Condurache; dorina.condurache{at}


Few cases of pouch-related cancers have been reported in inflammatory bowel disease, and squamous cell carcinoma (SCC) is very rare. We have reviewed the published literature searching the online databases PubMed and Medline. Since 1979, there have been eight cases of SCC developing after restorative proctocolectomy in ulcerative colitis. To date, there have been no reported cases of SCC of the ileo-anal pouch in Crohn’s disease. We present the case of a 59-year-old woman who underwent colectomy with ileal pouch-anal anastomosis for Crohn’s disease during the 1990s. The patient was noted to be anaemic and was experiencing significant weight loss with poor pouch function in 2019. Endoscopy with histology and radiological investigation revealed the presence of SCC of the pouch. This was subsequently treated with surgical therapy and chemoradiotherapy.

  • Crohn's disease
  • oncology
  • surgery

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  • Contributors The four authors provided significant contributions to the case report. DGC and JPS came up with the concept of the manuscript. DGC and JPS conducted the literature review and drafted the manuscript. ALH and AA provided supervision and critical revisions of the manuscript. DGC gave informed consent.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.