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Case report
Adenoid cystic carcinoma and chronic lymphocytic leukaemia: synchronous presentations in the lung
  1. Philip S Webb1,
  2. Yu Zhi Zhang2,
  3. Kirsten Burrell3 and
  4. Georges Sinclair4,5
  1. 1Oncology and Haematology Directorate, Oxford University Hospitals NHS Foundation Trust, Oxford, UK
  2. 2Department of Histopathology, Royal Brompton and Harefield NHS Foundation Trust, London, UK
  3. 3Department of Radiotherapy, Royal Berkshire NHS Foundation Trust, Reading, UK
  4. 4Department of Oncology, Royal Berkshire NHS Foundation Trust, Reading, UK
  5. 5Department of Neurosurgery, Bezmialem Vakif University, Istanbul, Turkey
  1. Correspondence to Dr Philip S Webb; pwebb1{at}doctors.org.uk

Abstract

A 59-year-old male active smoker presented with a 6-month history of cough and breathlessness and was found to have a right upper lobe mass. Histology revealed this to be an adenoid cystic carcinoma (ACC) of the lung, while local lymph node dissection revealed a synchronous diagnosis of chronic lymphocytic leukaemia (CLL). The connection between CLL and solid organ malignancy is well documented, but the reporting of ACC in this context is novel. Mechanisms linking the two processes are revealed with the possibility of causality, and heightened vigilance for the development of primary lung tumours in CLL, and their management, is recommended.

  • lung cancer (oncology)
  • haematology (incl blood transfusion)

https://doi.org/10.1136/bcr-2020-236074

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    Footnotes

    • Contributors PSW synthesised the literature, wrote the background and discussion and produced revisions of the case report. YZZ collated and presented relevant histopathological images. KB produced cross-sectional imaging. GS provided the case description and edited revisions of the case report. All authors approved the final submission.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Patient consent for publication Obtained.

    • Provenance and peer review Not commissioned; externally peer-reviewed.